Eosinophil-expressed galectin-3 regulates cell trafficking and migration

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Eosinophil-expressed galectin-3 regulates cell trafficking and migration

Galectin-3 (Gal-3), a β galactoside-binding lectin, is implicated in the pathogenesis of allergic airway inflammation and allergen-challenged mice deficient in Gal-3 (Gal-3(-/-)) exhibit decreased airway recruitment of eosinophils (Eos). Gal-3 is expressed and secreted by several cell types and can thus function extracellularly and intracellularly to regulate a variety of cellular responses. We...

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Trafficking and cell migration.

The migration of single cells and epithelial sheets is of great importance for gastrulation and organ formation in developing embryos and, if misregulated, can have dire consequences e.g. during cancer metastasis. A keystone of cell migration is the regulation of adhesive contacts, which are dynamically assembled and disassembled via endocytosis. Here, we discuss some of the basic concepts abou...

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ژورنال

عنوان ژورنال: Frontiers in Pharmacology

سال: 2013

ISSN: 1663-9812

DOI: 10.3389/fphar.2013.00037